Strategies in Trauma and Limb Reconstruction

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VOLUME 8 , ISSUE 2 ( August, 2013 ) > List of Articles

Original Article

Limb trauma: the use of an advanced wound care device in the treatment of full-thickness wounds

L. Vaienti, A. Marchesi, G. Palitta, R. Gazzola, P. C. Parodi, F. Leone

Keywords : Upper limb, Lower limb, Hyaluronic acid, Full-thickness wound

Citation Information : Vaienti L, Marchesi A, Palitta G, Gazzola R, Parodi PC, Leone F. Limb trauma: the use of an advanced wound care device in the treatment of full-thickness wounds. 2013; 8 (2):111-115.

DOI: 10.1007/s11751-013-0165-8

License: CC BY-NC-SA 4.0

Published Online: 31-08-2013

Copyright Statement:  Copyright © 2013; The Author(s).


This is an observational case series of 15 patients with full-thickness traumatic wound defects treated with a dermal substitute. There were 8 male and 7 female patients with a mean age of 36.6 years. Eight patients had trauma to the lower limbs and 7 were of the upper limbs, with the average lesion size 104.4 cm2 (range 6–490 cm2). The time to complete healing had a mean average time of 26.8 days (range 16–60 days). All patients went on to successful repair with 6 patients requiring a second application of the substitute and 5 patients needing split thickness skin grafts. Infection was recorded in one patient.

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  1. Gravante G, Sorge R, Merone A, Tamisani AM, Di Lonardo A, Scalise A, Doneddu G, Melandri D, Stracuzzi G, Onesti MG, Cerulli P, Pinn R, Esposito G (2010) Hyalomatrix PA in burn care practice: results from a national retrospective survey, 2005 to 2006. Ann Plast Surg 64(1):69-79
  2. Volpi N, Schiller J, Stern R, Soltés L (2009) Role, metabolism, chemical modifications and applications of Hyaluronan. Curr Med Chem 16(14):1718-1745
  3. Balazs EA, Laurent TC, Jeanloz RW (1986) Nomenclature of hyaluronic acid. Biochem J. 235:903
  4. Foschi D, Castoldi L, Radaelli E, Abelli P, Calderini G, Rastrelli A, Mariscotti C, Marazzi M, Trabucchi E (1990) Hyaluronic acid prevents oxygen free-radical damage to granulation tissue: a study in rats. Int J Tissue React 12:333
  5. Weigel PH, Frost SJ, McGary CT, LeBoeuf RD (1988) The role of hyaluronic acid in inflammation and wound healing. Int J Tissue React 10:355
  6. King SR, Hickerson WL, Proctor KG (1991) Beneficial actions of exogenous hyaluronic acid on wound healing. Surgery 109:76
  7. Voinchet V, Vasseur P, Kern J (2006) Efficacy and safety of hyaluronic acid in the management of acute wounds. Am J Clin Dermatol 7:353
  8. Campoccia D, Doherty P, Radice M, Brun P, Abatangelo G, Williams DF (1998) Semisynthetic resorbable materials from hyaluronan esterification. Biomaterials 19:2101
  9. West DC, Hampson IN, Arnold F, Kumar S (1985) Angiogenesis induced by degradation products of hyaluronic acid. Science 228:1324
  10. Rooney P, Kumar S (1993) Inverse relationship between hyaluronan and collagens in development and angiogenesis. Differentiation 54:1
  11. Barbucci R, Magnani A, Baszkin A, Da Costa ML, Bauser H, Hellwig G, Martuscelli E, Cimmino S (1993) Physico-chemical surface characterisation of hyaluronic acid derivatives as a new class of biomaterials. J Biomater Sci Polym Ed 4:245
  12. Gravante G, Delogu D, Giordan N, Morano G, Montone A, Esposito G (2007) The use of Hyalomatrix PA in the treatment of deep partial-thickness burns. J Burn Care Res. 28(2):269-274
  13. Perrot P, Dellière V, Brancati A, Duteille F (2011) Hyalomatrix PA(®) in skin substitutes. About 10 cases. Ann Chir Plast Esthet 56(2):107-111. doi:10.1016/j.anplas.2010.10.006
  14. Iannitti T, Lodi D, Palmieri B (2011) Intra-articular injections for the treatment of osteoarthritis: focus on the clinical use of hyaluronic acid. Drugs R D 11(1):13-27
  15. Eyigör C, Pirim A, Eyigör S, Uyar M (2010) Efficacy of intraarticular hyaluronic acid injection through a lateral approach under fluoroscopic control for advanced hip osteoarthritis. Agri. 22(4):139-144
  16. Myers SR, Partha VN, Soranzo C, Price RD, Navsaria HA (2007) Hyalomatrix: a temporary epidermal barrier, hyaluronan delivery, and neodermis induction system for keratinocyte stem cell therapy. Tissue Eng 13(11):2733-2741. doi:10.1089/ten.2007.0109
  17. West DC, Hampson IN, Arnold F, Kumar S (1991) Angiogenesis induced by degradation products of hyaluronic acid. Science 228:1324
  18. Kangesu T, Manek S, Terenghi G, Gu XH, Navsaria HA, Polak JM, Green CJ, Leigh IM (1998) Nerve and blood vessel growth in response to grafted dermis and cultured keratinocytes. Plast Reconstr Surg 101:1029
  19. Jaworski DM, Kelly GM, Hockfield S (1995) The CNS specific hyaluronan-binding protein BEHAB is expressed in ventricular zones coincident with gliogenesis. J Neurosci 15:1352
  20. Price RD, Das-Gupta V, Leigh IM, Navsaria HA (2006) A comparison of tissue-engineered hyaluronic acid dermal matrices in a human wound model. Tissue Eng 12(10):2985-2995
  21. Harris PA, di Francesco F, Barisoni D, Leigh IM, Navsaria HA (1999) Use of hyaluronic acid and cultured autologous keratinocytes and fibroblasts in extensive burns [letter]. Lancet 353:35
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