Clinical Outcome following Management of Severe Osteomyelitis due to Pin Site Infection
Florian A Frank, Eoghan Pomeroy, Andrew J Hotchen, David Stubbs, Jamie Y Ferguson, Martin McNally
Keywords :
Local antibiotics, One-stage surgery, Osteomyelitis, Pin site infection, Retrospective cohort study
Citation Information :
Frank FA, Pomeroy E, Hotchen AJ, Stubbs D, Ferguson JY, McNally M. Clinical Outcome following Management of Severe Osteomyelitis due to Pin Site Infection. 2024; 19 (1):21-25.
Aim: This study has investigated cases of pin site infection (PSI) which required surgery for persistent osteomyelitis (OM) despite pin removal.
Materials and methods: Patients requiring surgery for OM after PSI between 2011 and 2021 were included in this retrospective cohort study. Single-stage surgery was performed in accordance with a protocol at one institution. This involved deep sampling, debridement, implantation of local antibiotics, culture-specific systemic antibiotics and soft tissue closure. A successful outcome was defined as an infection-free interval of at least 24 months following surgery.
Results: Twenty-seven patients were identified (the sites were 22 tibias, 2 humeri, 2 calcanei, 1 radius); about 85% of them were males with a median age of 53.9 years. The majority of infections (21/27) followed fracture treatment. Fifteen patients were classified as BACH uncomplicated and 12 were BACH complex. Staphylococci were the most common pathogens, polymicrobial infections were detected in five cases (19%). Seven patients required flap coverage which was performed in the same operation.
After a median of 3.99 years (2.00–8.05) follow-up, all patients remained infection free at the site of the former OM. Wound leakage after local antibiotic treatment was seen in 3/27 (11.1%) cases but did not require further treatment.
Conclusion: Osteomyelitis after PSI is uncommon but has major implications for the patient as 7 patients needed flap coverage. This reinforces the need for careful pin placement and pin site care to prevent deep infection. These infections were treated in accordance with a protocol and were not managed simply by curettage. All patients treated in this manner remained infection-free after a minimum follow-up of 2 years suggesting that this protocol is effective.
Clinical significance: Pin site infection is a very common complication in external fixation. The sequela of a chronic pin site OM is rare but the implications to the patient are huge. In this series, more than a quarter of patients required flap coverage as part of the treatment of the deep infection.
Hadeed A, Werntz RL, Varacallo M. External Fixation Principles and Overview. StatPearls. Treasure Island (FL); 2023.
Bible JE, Mir HR. External fixation: Principles and applications. J Am Acad Orthop Surg 2015;23(11):683–690. DOI: 10.5435/JAAOS-D-14-00281.
Bafor A, Gehred A, Chimutengwende–Gordon M, et al. Future directions in the prevention of pin-site infection: A scoping review. J Limb Lengthening Reconstr 2022;8(Suppl. 1):S69–S80. DOI: 10.4103/jllr.jllr_2_22.
Iobst CA. Pin–track infections: Past, present, and future. J Limb Lengthening Reconstr 2017;3(2):78–84. DOI: 10.4103/jllr.jllr_17_17.
Kazmers NH, Fragomen AT, Rozbruch SR. Prevention of pin site infection in external fixation: A review of the literature. Strategies Trauma Limb Reconstr 2016;11(2):75–85. DOI: 10.1007/s11751-016-0256-4.
Jauregui JJ, Bor N, Thakral R, et al. Life- and limb-threatening infections following the use of an external fixator. Bone Joint J 2015;97-B(9):1296–300. DOI: 10.1302/0301-620X.97B9.35626.
Ferreira N, Marais LC. Prevention and management of external fixator pin track sepsis. Strategies Trauma Limb Reconstr 2012;7(2):67–72. DOI: 10.1007/s11751-012-0139-2.
Arveladze S, Moriarty F, Jennison T. The influence of pin material and coatings on the incidence of pin site infection after external fixation. J Limb Lengthening Reconstr 2022;8(Suppl. 1):S16–S23. DOI: 10.4103/jllr.jllr_35_21.
Fridberg M, Bue M, Rölfing JD, et al. Host factors and risk of pin site infection in external fixation: A systematic review examining age, body mass index, smoking, and comorbidities including diabetes. J Limb Lengthening Reconstr 2022;8(Suppl. 1):S3–S15. DOI: 10.4103/jllr.jllr_32_21.
Bue M, Bjarnason AÓ, Rölfing JD, et al. Prospective evaluation of pin site infections in 39 patients treated with external ring fixation. J Bone Jt Infect 2021;6(5):135–140. DOI: 10.5194/jbji-6-135-2021.
Liu K, Abulaiti A, Liu Y, et al. Risk factors of pin tract infection during bone transport using unilateral external fixator in the treatment of bone defects. BMC Surg 2021;21(1):377. DOI: 10.1186/s12893-021-01384-z.
Ceroni D, Grumetz C, Desvachez O, et al. From prevention of pin–tract infection to treatment of osteomyelitis during paediatric external fixation. J Child Orthop 2016;10(6):605–612. DOI: 10.1007/s11832-016-0787-8.
Ktistakis I, Guerado E, Giannoudis PV. Pin-site care: Can we reduce the incidence of infections? Injury 2015;46(Suppl. 3):S35–S39. DOI: 10.1016/S0020-1383(15)30009-7.
Jennison T, McNally M, Pandit H. Prevention of infection in external fixator pin sites. Acta Biomater 2014;10(2):595–603. DOI: 10.1016/j.actbio.2013.09.019.
Camathias C, Valderrabano V, Oberli H. Routine pin tract care in external fixation is unnecessary: A randomised, prospective, blinded controlled study. Injury 2012;43(11):1969–1973. DOI: 10.1016/j.injury.2012.08.010.
Parameswaran AD, Roberts CS, Seligson D, et al. Pin tract infection with contemporary external fixation: How much of a problem? J Orthopaedic Trauma 2003;17(7):503–507. DOI: 10.1097/00005131-200308000-00005.
Green SA, Ripley MJ. Chronic osteomyelitis in pin tracks. J Bone Joint Surg Am 1984;66(7):1092–1098. PMID: 6384221.
Saini AK, Grey JP, Venter R, et al. Hydrosurgical debridement of grade VI external fixator pin site infection. J Limb Lengthening Reconstr 2022;8(1):84–87. DOI: 10.4103/jllr.jllr_6_22.
Cierny G 3rd, Mader JT, Penninck JJ. A clinical staging system for adult osteomyelitis. Clin Orthop Relat Res. 2003(414):7–24. DOI: 10.1097/01.blo.0000088564.81746.62.
Nguyen VD, London J, Cone RO III. Ring sequestrum: Radiographic characteristics of skeletal fixation pin–tract osteomyelitis. Radiology 1986;158(1):129–131. DOI: 10.1148/radiology.158.1.3940369.
Metsemakers WJ, Morgenstern M, McNally MA, et al. Fracture-related infection: A consensus on definition from an international expert group. Injury 2018;49(3):505–510. DOI: 10.1016/j.injury.2017. 08.040.
Frank FA, Stubbs D, Ferguson JY, et al. A practical definition of pin site infection. Injury 2023;55(2):111230. DOI: 10.1016/j.injury.2023.111230.
Checketts RG, MacEachern AG, Otterburn M. Pin track infection: definition, incidence and prevention. Int J Orthop Trauma Suppl 1993;3:16–18. DOI: 10.1007/978-1-4471-0691-3_11.
Checketts RG, MacEachem AG, Otterburn M. Pin track infection and the principles of pin site care. In: De Bastiani G, Apley AG, Goldberg A, editors. Orthofix External Fixation in Trauma and Orthopaedics. London: Springer London; 2000, pp. 97–103.
Hotchen AJ, Dudareva M, Ferguson JY, et al. The BACH classification of long bone osteomyelitis. Bone Joint Res 2019;8(10):459–468. DOI: 10.1302/2046-3758.810.BJR-2019-0050.R1.
Dudareva M, Barrett LK, Morgenstern M, et al. Providing an evidence base for tissue sampling and culture interpretation in suspected fracture-related infection. J Bone Joint Surg Am 2021;103(11):977–983. DOI: 10.2106/JBJS.20.00409.
Sigmund IK, Yeghiazaryan L, Luger M, et al. Three to six tissue specimens for histopathological analysis are most accurate for diagnosing periprosthetic joint infection. Bone Joint J 2023; 105-B(2):158–165. DOI: 10.1302/0301-620X.105B2.BJJ-2022-0859.R1.
Morgenstern M, Athanasou NA, Ferguson JY, et al. The value of quantitative histology in the diagnosis of fracture-related infection. Bone Joint J 2018;100-B(7):966–972. DOI: 10.1302/0301-620X.100B7.BJJ-2018-0052.R1.
Dudareva M, Hotchen AJ, Ferguson J, et al. The microbiology of chronic osteomyelitis: Changes over ten years. J Infection 2019;79(3):189–198. DOI: 10.1016/j.jinf.2019.07.006.
Patel KH, Gill LI, Tissingh EK, et al. Microbiological profile of fracture related infection at a UK major trauma centre. Antibiotics (Basel) 2023;12(9). DOI: 10.1302/2046-3758.810.BJR-2019-0050.R1.
Lorentzen AK, Engel L, Gottlieb H, et al. One-stage treatment of chronic osteomyelitis with an antibiotic-loaded biocomposite and a local or free flap. European J Plastic Surg 2021;44(3):367–374. DOI: 10.1007/s00238-020-01754-5.
Pesch S, Hanschen M, Greve F, et al. Treatment of fracture-related infection of the lower extremity with antibiotic-eluting ceramic bone substitutes: Case series of 35 patients and literature review. Infection 2020;48(3):333–344. DOI: 10.1007/s15010-020-01418-3.
McNally MA, Ferguson JY, Scarborough M, et al. Mid- to long-term results of single-stage surgery for patients with chronic osteomyelitis using a bioabsorbable gentamicin-loaded ceramic carrier. Bone Joint J 2022;104-B(9):1095–1100. DOI: 10.1302/0301-620X.104B9.BJJ-2022-0396.R1.
Hotchen AJ, Dudareva M, Corrigan RA, et al. Can we predict outcome after treatment of long bone osteomyelitis? Bone Joint J 2020;102-B(11):1587–1596. DOI: 10.1302/0301-620X.102B11.BJJ-2020-0284.R1.
Olesen UK, Pedersen NJ, Eckardt H, et al. The cost of infection in severe open tibial fractures treated with a free flap. Int Orthop 2017;41(5):1049–1055. DOI: 10.1007/s00264-016-3337-6.
Thakore RV, McClure DJ, Sathiyakumar V, et al. The effect of flap coverage on length of stay and costs for patients with fractures of the tibia. Plast Reconstr Surg 2014;133(3):444e–445e. DOI: 10.1097/01.prs.0000438442.40282.bd.
Kuehl R, Tschudin-Sutter S, Morgenstern M, et al. Time-dependent differences in management and microbiology of orthopaedic internal fixation-associated infections: An observational prospective study with 229 patients. Clin Microbiol Infect 2019;25(1):76–81. DOI: 10.1016/j.cmi.2018.03.040.
Ferguson J, Bourget–Murray J, Stubbs D, et al. A comparison of clinical and radiological outcomes between two different biodegradable local antibiotic carriers used in the single-stage surgical management of long bone osteomyelitis. Bone Joint Res 2023;12(7):412–422. DOI: 10.1302/2046-3758.127.BJR-2022-0305.R2.
Nutt J, Sinclair L, Graham SM, et al. Identification of fine wire and half-pin loosening for external fixators: A systematic review. J Limb Lengthening Reconst 2022;8(Suppl. 1):S51–S58. DOI: 10.4103/jllr.jllr_33_21.